A new VR tool, powered by the same technology as the Fortnite video game, helps chemists visualize the structure of complex molecules and develop new drugs to treat diseases.
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| © C4X Discovery Scientists will be able to reach out and touch the molecules virtually |
By Edward Kiernan and Nell Lewis, CNN
The same technology that's revolutionizing video games is being used
to develop new drugs and fight some of the world's deadliest diseases.
Chemists at C4X Discovery
are using the virtual reality technology behind popular game Fortnite
to visualize the structure of complex molecules. The tool, called
4Sight, has already been used to create a drug that is now in
development to treat addiction.
Biochemists are also using the technology to develop drugs to tackle other diseases, such as cancer and Parkinson's.
Visualizing molecules
Scientists
traditionally used physical models to visualize drugs. But 4Sight
allows drug developers to grab hold of virtual molecules and see how
they move and respond to stimuli.
The key to drug design is
finding the right shape for the molecule to fit inside the targeted
protein pocket. If you get the wrong shape, the molecule could fail to
attach or even lodge in a different pocket, causing side effects.
"Moving
molecules around that are very complicated is so much easier by
grabbing them than by trying to use a mouse on a keyboard," says Craig
Fox, chief scientific officer at C4X Discovery.
The company claims
that the technology could help to reduce the margin of error during the
drug discovery process and enable scientists in different locations to
work on drug models in the same virtual room.
"It takes about 10
to 12 years to take a drug from the concept to the market," says Fox.
"It's often described as trying to find a needle in a haystack."
It's
also exceedingly expensive. It costs $2.6 billion on average to develop
a new prescription medicine that gains market approval, according to
the Tufts Center for Study of Drug Development.
Gamification
Anything
that helps speed up the development process and make it less laborious
for scientists is welcome. That's why C4X Discovery hired former video
game developer Phil Muwunga for the job of lead coder.
"The
software is the same as a game," says Muwunga, "we have a user base,
we're trying to get them to do tasks over and over again. And we're
trying to do it in a fun and intuitive fashion."
4Sight enables
scientists to visualize the unique 4-D data (measuring space and time as
well as length, width and depth) that C4X Discovery has accumulated on
small drug molecules.
"We are making a scientific tool that
scientists will use to improve their daily lives," says Muwunga. "That
being said I am from the games industry and I do treat this as a game —
people interact with it in the same way."
Other applications
Virtual reality has shown its potential in other areas of health care.
It's been used as a tool for medical training,
with students learning about the human anatomy through simulation.
Surgeons can use it to prepare for complicated surgeries, and it's even
been used as a tool for pain relief.
The global market for artificial and virtual reality in health care is projected to reach $5.1 billion by 2025, according to a 2017 report by Grand View Research.
The biggest pharma companies recognize potential of virtual reality tools. Novartis is using them in the drug design process, and Pfizer has experimented with applications from clinical trial design to manufacturing.
"We
believe immersive technologies can in the future provide cognitive
behavioral assistance and even telehealth," says Jim Mangione, Pfizer's
director of emerging technologies.
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